| title: |
| Identification of host cellular requirements for positive strand RNA viruses: Hepatitis
C virus and hepatitis E virus |
|
| contributing persons: |
| Lijo John[VerfasserIn] |
| Stephan Schaefer
, Prof. Dr. med.[AkademischeR BetreuerIn] |
 |
1016003706 |
|
Universität Rostock, Institut für Medizinische Mikrobiologie, Virologie und Hygiene |
| Hubert Bahl
, Prof. Dr. rer. nat.[AkademischeR BetreuerIn] |
|
132475170 |
|
Universität Rostock, Institut für Medizinische Mikrobiologie, Virologie und Hygiene |
|
| contributing corporate bodies: |
| Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
|
2147083-2 |
|
| |
| abstract: |
|
Investigation of the host cellular requirements of two positive strand RNA viruses,
by microarray, phospho-proteome array and by siRNA screening identified differential
expression of host genes during hepatitis C virus viral entry. Also my studies suggest
that NS4B regulates a newly identified oncogenic pathway. For hepatitis E virus, I
looked for the cellular effects conferred by the capsid protein ORF2, and the results
showed that ORF2 induced activation of CHOP did not lead to apoptosis which might
be due to the up regulation of anti-apoptotic chaperones like Hsp72.
[English] |
|
| document type: |
|
| institution: |
| Faculty for Mathematics and Natural Science |
|
| language: |
|
| subject class (DDC): |
|
| |
publication /
production: |
|
Rostock: Universität Rostock
|
|
2013
|
|
| |
| identifiers: |
|
| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000001067 |
| created / modified: |
05.11.2013 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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