Improved synthesis of 2,3-diacetamidouronates which are present in bacterial envelope

Jaya Shanmuga Prakash Jegannathan

doi:10.18453/rosdok_id00001253

Jaya Shanmuga Prakash Jegannathan

Improved synthesis of 2,3-diacetamidouronates which are present in bacterial envelope

Universität Rostock, 2014

https://doi.org/10.18453/rosdok_id00001253

Abstract: Diacetamidodideoxyuronic acids are components of lipopolysaccarides present in bacterial cell wall. There are very few publications reporting the preparation of this class of sugars. Hence, we present the synthesis of gluco-, galacto- and manno- configured sugars of 2,3-diacetamido-2,3-dideoxy-D-uronates. These monosaccharaides can be employed as glycosyl donors and acceptors in glycosylation reactions to produce larger glycosylates which can serve as components of antibiotics. Currently, the target molecules were synthesized in high yields with good reproducibility and scalability.

doctoral thesis free access

title:

Improved synthesis of 2,3-diacetamidouronates which are present in bacterial envelope

contributing persons:

Jaya Shanmuga Prakash Jegannathan[VerfasserIn]
	1046201883
Christian Vogel , Prof. Dr.[AkademischeR BetreuerIn]
	1011717204
	University of Rostock, Institute of Organic Chemistry
Till Opatz , Prof. Dr.[AkademischeR BetreuerIn]
	122688511
	University of Mainz, Institute of Organic Chemistry

contributing corporate bodies:

Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

abstract:

Diacetamidodideoxyuronic acids are components of lipopolysaccarides present in bacterial cell wall. There are very few publications reporting the preparation of this class of sugars. Hence, we present the synthesis of gluco-, galacto- and manno- configured sugars of 2,3-diacetamido-2,3-dideoxy-D-uronates. These monosaccharaides can be employed as glycosyl donors and acceptors in glycosylation reactions to produce larger glycosylates which can serve as components of antibiotics. Currently, the target molecules were synthesized in high yields with good reproducibility and scalability. [English]

document type:

doctoral thesis

institution:

Faculty of Mathematics and Natural Sciences

language:

English

subject class (DDC):

540 Chemistry & allied sciences

publication /
production:

Rostock: Universität Rostock

2014

identifiers: