title: |
The Impact of Tumor Necrosis Factor on Osteogenic Differentiation of Human Adipose
Tissue-Derived Stem Cells In Vitro |
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contributing persons: |
Achim Salamon[VerfasserIn] |
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1030279799 |
Dieter G. Weiss
, Prof. Dr. rer. nat.[AkademischeR BetreuerIn] |
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109199960 |
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Universität Rostock, Institut für Biowissenschaften, Abteilung Tierphysiologie |
Kirsten Peters
, PD Dr. rer. nat. et med. habil.[AkademischeR BetreuerIn] |
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Universitätsmedizin Rostock, Arbeitsbereich Zellbiologie |
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contributing corporate bodies: |
Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
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2147083-2 |
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abstract: |
Chronic inflammatory diseases are characterized by elevated levels of tumor necrosis
factor (TNF) and decreasing bone mineral density. TNF promotes differentiation of
bone resorbing osteoclasts from their hematopoietic precursors. Its impact on differentiation
of mesenchymal precursors of bone forming osteoblasts isolated from adipose (ASC)
was largely unknown. I found that TNF did neither induce osteoblastic differentiation
of ASC nor exhibited an impact on osteoblastic differentiation in vitro. Thus, TNF
mediates osteolysis in vivo presumably mainly by its pro-osteoclastogenic effect.
[English] |
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document type: |
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institution: |
Faculty of Mathematics and Natural Sciences |
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language: |
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subject class (DDC): |
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publication / production: |
Rostock
Rostock: Universität Rostock
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2014
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identifiers: |
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access condition: |
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license/rights statement: |
all rights reserved This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
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RosDok id: |
rosdok_disshab_0000001109 |
created / modified: |
31.01.2014 / 08.08.2023
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metadata license: |
The metadata of this document was dedicated to the public domain (CC0 1.0 Universal Public Domain Dedication). |