The Impact of Tumor Necrosis Factor on Osteogenic Differentiation of Human Adipose Tissue-Derived Stem Cells In Vitro

Achim Salamon

doi:10.18453/rosdok_id00001288

Achim Salamon

The Impact of Tumor Necrosis Factor on Osteogenic Differentiation of Human Adipose Tissue-Derived Stem Cells In Vitro

Universität Rostock, 2014

https://doi.org/10.18453/rosdok_id00001288

Abstract: Chronic inflammatory diseases are characterized by elevated levels of tumor necrosis factor (TNF) and decreasing bone mineral density. TNF promotes differentiation of bone resorbing osteoclasts from their hematopoietic precursors. Its impact on differentiation of mesenchymal precursors of bone forming osteoblasts isolated from adipose (ASC) was largely unknown. I found that TNF did neither induce osteoblastic differentiation of ASC nor exhibited an impact on osteoblastic differentiation in vitro. Thus, TNF mediates osteolysis in vivo presumably mainly by its pro-osteoclastogenic effect.

Dissertation Freier Zugang

Titel:

The Impact of Tumor Necrosis Factor on Osteogenic Differentiation of Human Adipose Tissue-Derived Stem Cells In Vitro

Beteiligte Personen:

Achim Salamon[VerfasserIn]
	1030279799
Dieter G. Weiss , Prof. Dr. rer. nat.[AkademischeR BetreuerIn]
	109199960
	Universität Rostock, Institut für Biowissenschaften, Abteilung Tierphysiologie
Kirsten Peters , PD Dr. rer. nat. et med. habil.[AkademischeR BetreuerIn]
	Universitätsmedizin Rostock, Arbeitsbereich Zellbiologie

Beteiligte Körperschaften:

Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

Zusammenfassung:

Chronic inflammatory diseases are characterized by elevated levels of tumor necrosis factor (TNF) and decreasing bone mineral density. TNF promotes differentiation of bone resorbing osteoclasts from their hematopoietic precursors. Its impact on differentiation of mesenchymal precursors of bone forming osteoblasts isolated from adipose (ASC) was largely unknown. I found that TNF did neither induce osteoblastic differentiation of ASC nor exhibited an impact on osteoblastic differentiation in vitro. Thus, TNF mediates osteolysis in vivo presumably mainly by its pro-osteoclastogenic effect. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Mathematisch-Naturwissenschaftliche Fakultät

Sprache:

Englisch

Sachgruppe der DNB:

570 Biowissenschaften, Biologie

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock

2014