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Yvonne Schmitz

Compartmental modelling of the Wnt pathway : Elucidating the role of nucleo-cytoplasmic shuttling of beta-catenin and its antagonists

Universität Rostock, 2014

Abstract: The Wnt pathway plays a critical role in development and disease. The key player of the pathway is b-cat. In the nucleus, the complex formation of b-cat and TCF initiates target gene expression. Its activity is mainly regulated by retention and degradation by its antagonists APC, Axin and GSK3. Based on experimental findings, I develop and investigate compartmental models in order to analyse of the role of nucleo-cytoplasmic shuttling of these proteins in Wnt signalling. I show that the compartmental separation of b-cat and its antagonists yields an increase of the b-cat/TCF concentration.

doctoral thesis   free access    


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