| title: |
| Compartmental modelling of the Wnt pathway: Elucidating the role of nucleo-cytoplasmic
shuttling of beta-catenin and its antagonists |
|
| contributing persons: |
| Yvonne Schmitz[VerfasserIn] |
 |
1047564882 |
| Olaf Wolkenhauer
, Prof. Dr.[AkademischeR BetreuerIn] |
|
133515931 |
|
Universität Rostock, Systembiologie und Bioinformatik, Institut für Informatik |
| Adelinde M. Uhrmacher
, Prof. Dr. rer. nat. habil.[AkademischeR BetreuerIn] |
|
136258794 |
|
Universität Rostock, Modellierung und Simulation, Institut für Informatik |
| Helen M. Byrne
, Prof. Dr.[AkademischeR BetreuerIn] |
|
University of Oxford, Computational Biology, Mathematical Institute |
|
| contributing corporate bodies: |
| Universität Rostock, Fakultät für Informatik und Elektrotechnik[Grad-verleihende Institution] |
|
10085032-7 |
|
| |
| abstract: |
|
The Wnt pathway plays a critical role in development and disease. The key player of
the pathway is b-cat. In the nucleus, the complex formation of b-cat and TCF initiates
target gene expression. Its activity is mainly regulated by retention and degradation
by its antagonists APC, Axin and GSK3. Based on experimental findings, I develop and
investigate compartmental models in order to analyse of the role of nucleo-cytoplasmic
shuttling of these proteins in Wnt signalling. I show that the compartmental separation
of b-cat and its antagonists yields an increase of the b-cat/TCF concentration.
[English] |
|
| document type: |
|
| institution: |
| Faculty of Computer Science and Electrical Engineering |
|
| language: |
|
| subject class (DDC): |
| 000 Generalities, Science |
| 500 Natural sciences |
|
| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2014
|
|
| |
| identifiers: |
|
| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000001124 |
| created / modified: |
18.02.2014 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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