Universität Rostock, 2014
Abstract: Iron is an indispensable micronutrient for virtually all bacterial species. On the other hand, excess of iron could lead to formation of ROS, which could be toxic for the cell. Therefore, microorganisms have established a tight control on the intracellular iron content. The milestone of the bacterial iron-dependent response is the ferric uptake regulator (Fur) protein. In silico, biochemical and in vivo studies established the role of CAC1682 as a genuine iron-responsive regulator in the solvent-producing bacterium Clostridium acetobutylicum.
doctoral thesis free access