The role of the Fur protein for maintenance of iron homeostasis in the strictly anaerobic bacterium Clostridium acetobutylicum

Delyana Vasileva

doi:10.18453/rosdok_id00001315

Delyana Vasileva

The role of the Fur protein for maintenance of iron homeostasis in the strictly anaerobic bacterium Clostridium acetobutylicum

Universität Rostock, 2014

https://doi.org/10.18453/rosdok_id00001315

Abstract: Iron is an indispensable micronutrient for virtually all bacterial species. On the other hand, excess of iron could lead to formation of ROS, which could be toxic for the cell. Therefore, microorganisms have established a tight control on the intracellular iron content. The milestone of the bacterial iron-dependent response is the ferric uptake regulator (Fur) protein. In silico, biochemical and in vivo studies established the role of CAC1682 as a genuine iron-responsive regulator in the solvent-producing bacterium Clostridium acetobutylicum.

Dissertation Freier Zugang

Titel:

The role of the Fur protein for maintenance of iron homeostasis in the strictly anaerobic bacterium Clostridium acetobutylicum

Beteiligte Personen:

Delyana Vasileva[VerfasserIn]
	1049173546
Hubert Bahl , Prof. Dr.[AkademischeR BetreuerIn]
	132475170
	Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät, Institut für Biowissenschaften, Mikrobiologie
Martin Hagemann , Prof. Dr.[AkademischeR BetreuerIn]
	118119249
	Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät, Institut für Biowissenschaften, Pflanzenphysiologie

Beteiligte Körperschaften:

Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

Zusammenfassung:

Iron is an indispensable micronutrient for virtually all bacterial species. On the other hand, excess of iron could lead to formation of ROS, which could be toxic for the cell. Therefore, microorganisms have established a tight control on the intracellular iron content. The milestone of the bacterial iron-dependent response is the ferric uptake regulator (Fur) protein. In silico, biochemical and in vivo studies established the role of CAC1682 as a genuine iron-responsive regulator in the solvent-producing bacterium Clostridium acetobutylicum. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Mathematisch-Naturwissenschaftliche Fakultät

Sprache:

Englisch

Sachgruppe der DNB:

570 Biowissenschaften, Biologie

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock

2014