goto contents

Rostock University Publication Server
  1. Start
  2. E-publications
  3. Browse in e-publications
  4. Document

Xin Lai

A systems biology approach to unravel the cellular function of microRNAs

Universität Rostock, 2014

https://doi.org/10.18453/rosdok_id00001325

Abstract: The systems biology approach, combining biological data with mathematical modelling, provides the means to elucidate the role of miRNAs in signalling pathways and gene regulatory networks. The approach is characterised by a cyclic process, including biological network construction, mathematical modelling, simulation and experimental validation. Using this approach, I first investigate the regulatory role of miR-34a in a signalling pathway. Second, the investigation of the regulation of a miRNA target hub by multiple and cooperative miRNAs is presented.

doctoral thesis   free access    

title:
A systems biology approach to unravel the cellular function of microRNAs
other title:
Ein systembiologischer Ansatz zur Charakterisierung der zellulären Funktion von microRNAs [translated]
contributing persons:
Xin Lai[VerfasserIn]
1034831569
Olaf Wolkenhauer , Prof. Dr.[AkademischeR BetreuerIn]
133515931
Universität Rostock, Fakultät für Informatik und Elektrotechnik
Bernd Schmeck , Prof. Dr.[AkademischeR BetreuerIn]
Philipps-Universität Marburg
Rui Alves , Prof. Dr.[AkademischeR BetreuerIn]
Universidad de Lleida
contributing corporate bodies:
Universität Rostock, Fakultät für Informatik und Elektrotechnik[Grad-verleihende Institution]
10085032-7
 
abstract:
The systems biology approach, combining biological data with mathematical modelling, provides the means to elucidate the role of miRNAs in signalling pathways and gene regulatory networks. The approach is characterised by a cyclic process, including biological network construction, mathematical modelling, simulation and experimental validation. Using this approach, I first investigate the regulatory role of miR-34a in a signalling pathway. Second, the investigation of the regulation of a miRNA target hub by multiple and cooperative miRNAs is presented. [English]
document type:
doctoral thesis
institution:
Faculty of Computer Science and Electrical Engineering
language:
English
subject class (DDC):
000 Generalities, Science
570 Life science
 
publication /
production:		 Rostock
Rostock: Universität Rostock
2014
 
identifiers:
K10plus id: 782487505
DOI: 10.18453/rosdok_id00001325
URN: urn:nbn:de:gbv:28-diss2014-0077-5
PURL: https://purl.uni-rostock.de/rosdok/id00001325
 
access condition:
open access
license/rights statement:
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz).
RosDok id: rosdok_disshab_0000001146
created / modified: 02.04.2014 / 08.08.2023
metadata license: The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication).
fulltext

Persistent citation

https://doi.org/
10.18453/rosdok_id00001325

viewer
fulltext(13.8 MB) MD5
Dissertation_Lai_2014.pdf

Portals

OPACGVKDataCite Commons

Rights

all rights reserved

This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz).

Export

BibTeXEndNoteRISDublinCoreMODS

Share

UB Logo
Contact

Universitätsbibliothek Rostock
Digitale Bibliothek
und Publikationsdienste

digibib.ub(at)uni-rostock.de

Service

MyCoRe

powered by MyCoRe

© 2023 Rostock University Library