| title: |
| CD8+ T cell epitopes derived from the polyomavirus capsid protein VP1 |
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| contributing persons: |
| Jiju Mani[VerfasserIn] |
 |
1054106657 |
| Michael Schmitt
, Prof. Dr. med.[AkademischeR BetreuerIn] |
|
Universitätsklinikum Heidelberg, Medizinische Klinik V |
| Ulrike Gimsa
, apl. Prof. Dr. rer. nat. habil.[AkademischeR BetreuerIn] |
|
Leibniz-Institut für Nutztierbiologie, Institut für Verhaltensphysiologie |
|
| contributing corporate bodies: |
| Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
|
2147083-2 |
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| |
| abstract: |
|
One method for treatment of JCV and BKV-related diseases is by adoptive transfer of
virus-specific T-cells. Precursor frequency of JCV-capsid protein VP1-specific T-cells
was very low compared to other viruses. Optimized assays revealed JCV-specific T cells
with high avidity, peptide-specificity and high functional reactivity in long-term
cultures. Additionally, novel, naturally processed JCV-VP1-derived CD8+ T cell epitopes
were identified. These new data contribute to the development of therapies that, due
to their cross-reactivity, target both polyomaviruses-related diseases simultaneously.
[English] |
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| document type: |
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| institution: |
| Faculty of Mathematics and Natural Sciences |
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| language: |
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| subject class (DDC): |
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publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2014
|
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| identifiers: |
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| access condition: |
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| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000001170 |
| created / modified: |
31.07.2014 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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