Design and synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones and corresponding N-nucleosides : New purine isosters as potential drug-like scaffolds

Linda Supe

doi:10.18453/rosdok_id00001350

Linda Supe

Design and synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones and corresponding N-nucleosides : New purine isosters as potential drug-like scaffolds

Universität Rostock, 2014

https://doi.org/10.18453/rosdok_id00001350

Abstract: The work is devoted to study synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones with potential biological activity. 1H-pyrazolo[3,4-b]pyridin-3(2H)-one derived moieties were afforded using classical approaches involving [3+3] cyclocondensation of enamine fragment-containing heterocycle and bielectrophiles, inverse electron-demand Diels-Alder reaction, palladium-catalyzed C-C coupling reaction. N-nucleosides of purine analogues were synthesized using modified silyl Hilbert-Jones method. Scope and limitations of hydrogenation of pyridine ring of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones were studied.

doctoral thesis free access

title:

Design and synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones and corresponding N-nucleosides: New purine isosters as potential drug-like scaffolds

contributing persons:

Linda Supe[VerfasserIn]
	1054016976
Bernd Schmidt , Prof. Dr.[AkademischeR BetreuerIn]
	Universität Potsdam, Institut für Chemie
Jens Christoffers , Prof. Dr.[AkademischeR BetreuerIn]
	Carl von Ossietzky Universität Oldenburg, Institut für Reine und Angewandte Chemie

contributing corporate bodies:

Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

abstract:

The work is devoted to study synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones with potential biological activity. 1H-pyrazolo[3,4-b]pyridin-3(2H)-one derived moieties were afforded using classical approaches involving [3+3] cyclocondensation of enamine fragment-containing heterocycle and bielectrophiles, inverse electron-demand Diels-Alder reaction, palladium-catalyzed C-C coupling reaction. N-nucleosides of purine analogues were synthesized using modified silyl Hilbert-Jones method. Scope and limitations of hydrogenation of pyridine ring of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones were studied. [English]

document type:

doctoral thesis

institution:

Faculty of Mathematics and Natural Sciences

language:

English

subject class (DDC):

540 Chemistry & allied sciences

publication /
production:

Rostock: Universität Rostock

2014

identifiers: