title: |
Design and synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones and corresponding N-nucleosides:
New purine isosters as potential drug-like scaffolds |
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contributing persons: |
Linda Supe[VerfasserIn] |
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1054016976 |
Bernd Schmidt
, Prof. Dr.[AkademischeR BetreuerIn] |
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Universität Potsdam, Institut für Chemie |
Jens Christoffers
, Prof. Dr.[AkademischeR BetreuerIn] |
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Carl von Ossietzky Universität Oldenburg, Institut für Reine und Angewandte Chemie |
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contributing corporate bodies: |
Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
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2147083-2 |
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abstract: |
The work is devoted to study synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones with
potential biological activity. 1H-pyrazolo[3,4-b]pyridin-3(2H)-one derived moieties
were afforded using classical approaches involving [3+3] cyclocondensation of enamine
fragment-containing heterocycle and bielectrophiles, inverse electron-demand Diels-Alder
reaction, palladium-catalyzed C-C coupling reaction. N-nucleosides of purine analogues
were synthesized using modified silyl Hilbert-Jones method. Scope and limitations
of hydrogenation of pyridine ring of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones were studied.
[English] |
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document type: |
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institution: |
Faculty of Mathematics and Natural Sciences |
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language: |
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subject class (DDC): |
540 Chemistry & allied sciences |
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publication / production: |
Rostock: Universität Rostock
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2014
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identifiers: |
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access condition: |
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license/rights statement: |
all rights reserved This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
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RosDok id: |
rosdok_disshab_0000001171 |
created / modified: |
31.07.2014 / 08.08.2023
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metadata license: |
The metadata of this document was dedicated to the public domain (CC0 1.0 Universal Public Domain Dedication). |