Development and evaluation of biotechnological techniques for myocardial angiogenesis and functional recovery

Yue Zhang

doi:10.18453/rosdok_id00001368

Yue Zhang

Development and evaluation of biotechnological techniques for myocardial angiogenesis and functional recovery

Universität Rostock, 2014

https://doi.org/10.18453/rosdok_id00001368

Abstract: Myocardial infarction is an irreversible injury of the heart muscle leading to complex changes in ventricular construction. Hence, the reduction and repair of myocardial damage are great challenges in clinical research. The objective of the present work was the development of novel biomedical techniques for cardiac regeneration employing targeted gene transfer and biomaterial-based tissue engineering. Using a rat model of MI, the therapeutic effect of stable magnetic field-guided MNBs/AdhVEGF complexes was evaluated on the one hand and intracardiac matrigel injection on the other hand.

Dissertation Freier Zugang

Titel:

Development and evaluation of biotechnological techniques for myocardial angiogenesis and functional recovery

Weitere Titel:

Entwicklung und Evaluation von biotechnologischen Techniken für myokardiale Angiogenese und funktionale Genesung [übersetzt]

Beteiligte Personen:

Yue Zhang[VerfasserIn]
	1054099537
Gustav Steinhoff , Prof. Dr. med.[AkademischeR BetreuerIn]
	136129560
	Universität Rostock, Medizinische Fakultät
Jan Gimsa , Prof. Dr.[AkademischeR BetreuerIn]
	Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät
Hubert Bahl , Prof. Dr. rer. nat.[AkademischeR BetreuerIn]
	132475170
	Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät

Beteiligte Körperschaften:

Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

Zusammenfassung:

Myocardial infarction is an irreversible injury of the heart muscle leading to complex changes in ventricular construction. Hence, the reduction and repair of myocardial damage are great challenges in clinical research. The objective of the present work was the development of novel biomedical techniques for cardiac regeneration employing targeted gene transfer and biomaterial-based tissue engineering. Using a rat model of MI, the therapeutic effect of stable magnetic field-guided MNBs/AdhVEGF complexes was evaluated on the one hand and intracardiac matrigel injection on the other hand. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Mathematisch-Naturwissenschaftliche Fakultät

Sprache:

Englisch

Sachgruppe der DNB:

570 Biowissenschaften, Biologie

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock

2014