goto contents

Silvio Hering

Charakterisierung der Arginin Deiminase von Streptococcus pyogenes M49 und deren potentielle Anwendung in der Tumortherapie

Universität Rostock, 2014

Abstract: In this study we investigated the influence of the Arginine Deiminase on the amino acid and glucose metabolism from S. pyogenes but also on the virulence. Furthermore, the AD from S. pyogenes M49 was heterologously expressed, purified, and kinetically characterized. Futhermore, the impact of the purified AD on cell proliferation of arginine auxotrophic tumors was investigated. The AD showed an antiproliferative effects on glioblastoma cell lines and hepatocellular and colorectal carcinoma cell lines. The effects were significantly increased in combination with chemotherapeutics.

doctoral thesis   free access    


OPACGVKDataCite Commons


all rights reserved

This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz).