title: |
The role of minimal nerve injury in a new animal model for CRPS |
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contributing persons: |
Zi Wang[VerfasserIn] |
 |
1036251721 |
Brigitte Vollmar
, Prof. Dr. med.[AkademischeR BetreuerIn] |
 |
136319564 |
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Universität Rostock, Institut für Experimentelle Chirurgie |
Georg Gradl
, Universität Rostock, Abteilung für Unfall- und Wiederherstellungschirurgie[AkademischeR BetreuerIn] |
 |
121015688 |
|
Prof. Dr. med. |
Ralph Kayser
, PD. Dr. med.[AkademischeR BetreuerIn] |
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Universität Greifswald, Klinik für Orthopädie und Orthopädische Chirurgie |
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contributing corporate bodies: |
Universität Rostock, Universitätsmedizin[Grad-verleihende Institution] |
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1029510660 |
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abstract: |
Complex regional pain syndrome(CRPS) is a chronic neuropathic pain disease which
typically develops in distal extremities after trauma. The mechanism of CRPS is still
unknown. We combined a closed soft tissue trauma in the hindlimb of a rat and a minimal
nerve injury in the ipsilateral sciatic nerve to establish a new animal model for
CRPS. This model induced CRPS symptoms including pain, altered temperature, muscle
edema, regional inflammation and muscle cell apoptosis. However, most of the symptoms
disappeared within four weeks. This new model is not sufficient to induce an ongoing
CRPS.
[English] |
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document type: |
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institution: |
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language: |
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subject class (DDC): |
610 Medical sciences Medicine |
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publication / production: |
Rostock
Rostock: Universität Rostock
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2014
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identifiers: |
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access condition: |
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license/rights statement: |
all rights reserved This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
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RosDok id: |
rosdok_disshab_0000001230 |
created / modified: |
15.09.2014 / 08.08.2023
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metadata license: |
The metadata of this document was dedicated to the public domain (CC0 1.0 Universal Public Domain Dedication). |