The role of minimal nerve injury in a new animal model for CRPS

Zi Wang

doi:10.18453/rosdok_id00001409

Zi Wang

The role of minimal nerve injury in a new animal model for CRPS

Universität Rostock, 2014

https://doi.org/10.18453/rosdok_id00001409

Abstract: Complex regional pain syndrome(CRPS) is a chronic neuropathic pain disease which typically develops in distal extremities after trauma. The mechanism of CRPS is still unknown. We combined a closed soft tissue trauma in the hindlimb of a rat and a minimal nerve injury in the ipsilateral sciatic nerve to establish a new animal model for CRPS. This model induced CRPS symptoms including pain, altered temperature, muscle edema, regional inflammation and muscle cell apoptosis. However, most of the symptoms disappeared within four weeks. This new model is not sufficient to induce an ongoing CRPS.

Dissertation Freier Zugang

Titel:

The role of minimal nerve injury in a new animal model for CRPS

Beteiligte Personen:

Zi Wang[VerfasserIn]
	1036251721
Brigitte Vollmar , Prof. Dr. med.[AkademischeR BetreuerIn]
	136319564
	Universität Rostock, Institut für Experimentelle Chirurgie
Georg Gradl , Universität Rostock, Abteilung für Unfall- und Wiederherstellungschirurgie[AkademischeR BetreuerIn]
	121015688
	Prof. Dr. med.
Ralph Kayser , PD. Dr. med.[AkademischeR BetreuerIn]
	Universität Greifswald, Klinik für Orthopädie und Orthopädische Chirurgie

Beteiligte Körperschaften:

Universität Rostock, Universitätsmedizin[Grad-verleihende Institution]
	1029510660

Zusammenfassung:

Complex regional pain syndrome(CRPS) is a chronic neuropathic pain disease which typically develops in distal extremities after trauma. The mechanism of CRPS is still unknown. We combined a closed soft tissue trauma in the hindlimb of a rat and a minimal nerve injury in the ipsilateral sciatic nerve to establish a new animal model for CRPS. This model induced CRPS symptoms including pain, altered temperature, muscle edema, regional inflammation and muscle cell apoptosis. However, most of the symptoms disappeared within four weeks. This new model is not sufficient to induce an ongoing CRPS. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Universitätsmedizin

Sprache:

Englisch

Sachgruppe der DNB:

610 Medizin, Gesundheit

Veröffentlichung /
Entstehung:

Rostock: Universität Rostock

2014

Identifikatoren: