Gene mutations and losses of heterozygosity of TP53 and PTEN in colorectal cancer

Tareq Salem

doi:10.18453/rosdok_id00001422

Tareq Salem

Gene mutations and losses of heterozygosity of TP53 and PTEN in colorectal cancer

Universität Rostock, 2014

https://doi.org/10.18453/rosdok_id00001422

Abstract: This study was conducted to find out if the patterns of PTEN gene molecular aberration in colorectal carcinoma are consistent with the classic molecular features ascribed to a tumour suppressor gene. PTEN gene mutations and LOH were assayed in a series of 18 colorectal carcinomas. Three PTEN gene mutations were found in 1 tumour, complete loss of one allele(LOH)in 2 tumours and allelic imbalance (AI) in 6 tumours. LOH or AI did not target the 1 tumour with the PTEN gene mutations. The widely held belief of PTEN as a classical tumour suppressor gene is not supported by the findings from this study.

Dissertation Freier Zugang

Titel:

Gene mutations and losses of heterozygosity of TP53 and PTEN in colorectal cancer

Beteiligte Personen:

Tareq Salem[VerfasserIn]
	1060187329
Friedrich Prall , Prof. Dr. med[AkademischeR BetreuerIn]
	113623496
	Universität Rostock, Institut für Pathologie
Michael Linnebacher , PD Dr. rer. nat.[AkademischeR BetreuerIn]
	1028873808
	Universität Rostock, Klinik und Poliklinik für Chirurgie
Mathias Evert , Prof. Dr. med.[AkademischeR BetreuerIn]
	Universität Greifswald, Institut für Pathologie

Beteiligte Körperschaften:

Universität Rostock, Universitätsmedizin[Grad-verleihende Institution]
	1029510660

Zusammenfassung:

This study was conducted to find out if the patterns of PTEN gene molecular aberration in colorectal carcinoma are consistent with the classic molecular features ascribed to a tumour suppressor gene. PTEN gene mutations and LOH were assayed in a series of 18 colorectal carcinomas. Three PTEN gene mutations were found in 1 tumour, complete loss of one allele(LOH)in 2 tumours and allelic imbalance (AI) in 6 tumours. LOH or AI did not target the 1 tumour with the PTEN gene mutations. The widely held belief of PTEN as a classical tumour suppressor gene is not supported by the findings from this study. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Universitätsmedizin

Sprache:

Englisch

Sachgruppe der DNB:

610 Medizin, Gesundheit

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock

2014