| title: |
| The role of gap junctional intercellular communication and connexins in the differentiation
of human neural progenitor cells |
|
| contributing persons: |
| Heiko Lemcke[VerfasserIn] |
 |
1049755472 |
| Sergei Kuznetsov
, Dr. rer. nat.[AkademischeR BetreuerIn] |
|
Universität Rostock, Institut für Biowissenschaften, Abteilung Tierphysiologie |
| Arndt Rolfs
, Prof. Dr. med.[AkademischeR BetreuerIn] |
|
136256864 |
|
Universität Rostock, Universitätsmedizin, Albrecht Kossel Institut für Neuroregeneration |
|
| contributing corporate bodies: |
| Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
|
2147083-2 |
|
| |
| abstract: |
|
Our findings provide a dual function of connexin43 (Cx43) and gap junctional intercellular
communication (GJIC) in the neural development of human progenitor cells. 1) GJIC
accompanied by high Cx43 expression is necessary to maintain cells in a proliferative
state by mediating the mitogenic effects of growth factors. 2) GJIC is required to
complete neuronal differentiation, including the establishment of a neural network.
However, uncoupling of cells is crucial in the early stage of differentiation during
cell fate commitment. Further, we showed that Cx43 regulates neuronal cell-fate.
[English] |
|
| document type: |
|
| institution: |
| Faculty of Mathematics and Natural Sciences |
|
| language: |
|
| subject class (DDC): |
| 610 Medical sciences Medicine |
| 570 Life science |
|
| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2015
|
|
| |
| identifiers: |
|
| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000001278 |
| created / modified: |
06.02.2015 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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