Asymmetric hydrogenation and hydroformylation of 1,1-disubstituted olefins

Lutz Domke

doi:10.18453/rosdok_id00001476

Lutz Domke

Asymmetric hydrogenation and hydroformylation of 1,1-disubstituted olefins

Universität Rostock, 2015

https://doi.org/10.18453/rosdok_id00001476

Abstract: Asymmetric hydrogenation as well as hydroformylation of 1,1-disubstituted olefins were investigated. Thus, an O-silylprotected dehydro lactate, a N,O-ketene acetal and a range of dehydro beta2-homoalanine derivatives were hydrogenated enantioselectively yielding chiral products with high stereoselectivities. Furthermore, the rhodium-catalyzed asymmetric hydroformylation of an alpha-phosphorylated styrene derivative was examined and the scope could be expanded using new phosphite-phosphoramidite ligands. In addition, HP-NMR experiments gave some indication of the active catalyst-complex.

Dissertation Freier Zugang

Titel:

Asymmetric hydrogenation and hydroformylation of 1,1-disubstituted olefins

Beteiligte Personen:

Lutz Domke[VerfasserIn]
	1064972349
Armin Börner , Prof. Dr.[AkademischeR BetreuerIn]
	Universität Rostock, Institut für Chemie
Montserrat Diéguez , Prof. Dr.[AkademischeR BetreuerIn]
	Universitat Rovira í Virgili, Tarragona, Spanien, Departament de Quimica Fisica í Inorganica

Beteiligte Körperschaften:

Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

Zusammenfassung:

Asymmetric hydrogenation as well as hydroformylation of 1,1-disubstituted olefins were investigated. Thus, an O-silylprotected dehydro lactate, a N,O-ketene acetal and a range of dehydro beta2-homoalanine derivatives were hydrogenated enantioselectively yielding chiral products with high stereoselectivities. Furthermore, the rhodium-catalyzed asymmetric hydroformylation of an alpha-phosphorylated styrene derivative was examined and the scope could be expanded using new phosphite-phosphoramidite ligands. In addition, HP-NMR experiments gave some indication of the active catalyst-complex. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Mathematisch-Naturwissenschaftliche Fakultät

Sprache:

Englisch

Sachgruppe der DNB:

540 Chemie

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock

2015