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Muhammad Shakeel Ahmed Abbasi

Annulation reactions of heterocyclic chlorovinyl-aldehydes : synthesis of functionalized 6H-benzo[c]chromen-6-ones (biaryl lactones), 6H-benzo[c]chromenes and heteroannulated pyridines

Universität Rostock, 2015

Abstract: A simple and convenient domino cycloaromatization approach towards the synthesis of novel benzo[c]chromen-6-ones and benzo[c]chromenes by treatment of heterocyclic chlorovinyl-aldehydes with active methylene compounds has been developed. In another strategy novel biaryl lactones were prepared by Sonogashira cross-coupling and base catalyzed reactions of 4-chloro-2-oxo-2H-chromene-3-carbaldehyde with terminal alkynes and 1, 3-dicarbonyl compounds.Finally some heterocyclic chlorovinyl-aldehydes were treated with electron rich heterocyclic amines to afford novel heteroannulated pyridines.

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