Annulation reactions of heterocyclic chlorovinyl-aldehydes : synthesis of functionalized 6H-benzo[c]chromen-6-ones (biaryl lactones), 6H-benzo[c]chromenes and heteroannulated pyridines

Muhammad Shakeel Ahmed Abbasi

doi:10.18453/rosdok_id00001536

Muhammad Shakeel Ahmed Abbasi

Annulation reactions of heterocyclic chlorovinyl-aldehydes : synthesis of functionalized 6H-benzo[c]chromen-6-ones (biaryl lactones), 6H-benzo[c]chromenes and heteroannulated pyridines

Universität Rostock, 2015

https://doi.org/10.18453/rosdok_id00001536

Abstract: A simple and convenient domino cycloaromatization approach towards the synthesis of novel benzo[c]chromen-6-ones and benzo[c]chromenes by treatment of heterocyclic chlorovinyl-aldehydes with active methylene compounds has been developed. In another strategy novel biaryl lactones were prepared by Sonogashira cross-coupling and base catalyzed reactions of 4-chloro-2-oxo-2H-chromene-3-carbaldehyde with terminal alkynes and 1, 3-dicarbonyl compounds.Finally some heterocyclic chlorovinyl-aldehydes were treated with electron rich heterocyclic amines to afford novel heteroannulated pyridines.

Dissertation Freier Zugang

Titel:

Annulation reactions of heterocyclic chlorovinyl-aldehydes: synthesis of functionalized 6H-benzo[c]chromen-6-ones (biaryl lactones), 6H-benzo[c]chromenes and heteroannulated pyridines

Beteiligte Personen:

Muhammad Shakeel Ahmed Abbasi[VerfasserIn]
	1071809431
Peter Langer , Prof. Dr.[AkademischeR BetreuerIn]
	132314614
	University of Rostock, Institute of Chemistry
Bernd Schmidt , Prof. Dr.[AkademischeR BetreuerIn]
	University of Potsdam, Institute of Chemistry

Beteiligte Körperschaften:

Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

Zusammenfassung:

A simple and convenient domino cycloaromatization approach towards the synthesis of novel benzo[c]chromen-6-ones and benzo[c]chromenes by treatment of heterocyclic chlorovinyl-aldehydes with active methylene compounds has been developed. In another strategy novel biaryl lactones were prepared by Sonogashira cross-coupling and base catalyzed reactions of 4-chloro-2-oxo-2H-chromene-3-carbaldehyde with terminal alkynes and 1, 3-dicarbonyl compounds.Finally some heterocyclic chlorovinyl-aldehydes were treated with electron rich heterocyclic amines to afford novel heteroannulated pyridines. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Mathematisch-Naturwissenschaftliche Fakultät

Sprache:

Englisch

Sachgruppe der DNB:

540 Chemie

Veröffentlichung /
Entstehung:

Rostock: Universität Rostock

2015

Identifikatoren: