Osteoblast physiology and morphology on cell adhesive plasma-polymerized allylamine and ethylenediamine layers

Henrike Rebl

doi:10.18453/rosdok_id00001544

Henrike Rebl

Osteoblast physiology and morphology on cell adhesive plasma-polymerized allylamine and ethylenediamine layers

Universität Rostock, 2015

https://doi.org/10.18453/rosdok_id00001544

Abstract: The behavior of osteoblastic cells on two different amino-functionalized plasma polymer layers was investigated. A positive effect on cell adhesion, spreading and mobility of the adhesion protein vinculin was observed. The cells showed a very flat morphology so they literally melted with the surface structure. It was demonstrated that the chemical surface modification is dominant over surface topography. Comparative analyses revealed that not the density of the amino groups, but rather the general positive surface charge is responsible for the cell-attractive potential of the plasma layers.

Dissertation Freier Zugang

Titel:

Osteoblast physiology and morphology on cell adhesive plasma-polymerized allylamine and ethylenediamine layers

Weitere Titel:

Physiologie und Morphologie von Osteoblasten auf zell-adhäsiven plasma-polymerisierten Allylamin- und Ethylendiaminschichten [übersetzt]

Beteiligte Personen:

Henrike Rebl[VerfasserIn]
	1071873288
Barbara Nebe , Prof. Dr.[AkademischeR BetreuerIn]
	172943744
	Universitätsmedizin Rostock, Zentrum für Medizinische Forschung / Zellbiologie
Sergei Kuznetsov , PD Dr.[AkademischeR BetreuerIn]
	Universität Rostock, Biowissenschaften / Tierphysiologie
Uwe Pieles , Prof. Dr.[AkademischeR BetreuerIn]
	Hochschule für Life Sciences Muttenz, Schweiz, Institut für Chemie und Bioanalytik

Beteiligte Körperschaften:

Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

Zusammenfassung:

The behavior of osteoblastic cells on two different amino-functionalized plasma polymer layers was investigated. A positive effect on cell adhesion, spreading and mobility of the adhesion protein vinculin was observed. The cells showed a very flat morphology so they literally melted with the surface structure. It was demonstrated that the chemical surface modification is dominant over surface topography. Comparative analyses revealed that not the density of the amino groups, but rather the general positive surface charge is responsible for the cell-attractive potential of the plasma layers. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Mathematisch-Naturwissenschaftliche Fakultät

Sprache:

Englisch

Sachgruppe der DNB:

610 Medizin, Gesundheit

570 Biowissenschaften, Biologie

Veröffentlichung /
Entstehung:

Rostock: Universität Rostock

2015