title: |
The regenerative potential of the CD117+AT2R stimulated cell population in vitro and
in vivo |
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other title: |
Das regenerative Potential der CD117+AT2R stimulierten Zellpopulation in vitro und
in vivo
[translated]
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contributing persons: |
Marion Ludwig[VerfasserIn] |
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1075814340 |
Gustav Steinhoff
, Prof. Dr. med.[AkademischeR BetreuerIn] |
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136129560 |
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Universität Rostock, Klinik und Poliklinik für Herzchirurgie |
Ulrike Gimsa
, Prof. Dr. rer. nat.[AkademischeR BetreuerIn] |
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Universität Rostock; FBN Dummerstorf, Immunologie |
Ulrich Martin
, Prof. Dr. rer. nat.[AkademischeR BetreuerIn] |
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Medizinische Hochschule Hannover, Klinik für Thorax-, Herz- und Gefäßchirurgie |
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contributing corporate bodies: |
Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
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2147083-2 |
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abstract: |
Regarding innovative therapeutical approaches for cardiac regeneration, we thoroughly
investigated CD117+ and CD117+AT2R stimulated murine bone marrow stem cells. Electrophysiological
measurements and in vitro results indicated the differentiation into an endothelial-like
phenotype excluding a previously discussed development into cardiomyocytes. Cell implantation
into infarcted murine heart provoked a significant improvement of cardiac function.
AT2R triggered effects were not significantly different and should be analyzed in
interplay with its opposing receptor AT1.
[English] |
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document type: |
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institution: |
Faculty of Mathematics and Natural Sciences |
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language: |
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subject class (DDC): |
610 Medical sciences Medicine |
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publication / production: |
Rostock
Rostock: Universität Rostock
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2015
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identifiers: |
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access condition: |
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license/rights statement: |
all rights reserved This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
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RosDok id: |
rosdok_disshab_0000001417 |
created / modified: |
19.08.2015 / 08.08.2023
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metadata license: |
The metadata of this document was dedicated to the public domain (CC0 1.0 Universal Public Domain Dedication). |