| title: |
| The regenerative potential of the CD117+AT2R stimulated cell population in vitro and
in vivo |
|
| other title: |
| Das regenerative Potential der CD117+AT2R stimulierten Zellpopulation in vitro und
in vivo
[translated]
|
|
| contributing persons: |
| Marion Ludwig[VerfasserIn] |
 |
1075814340 |
| Gustav Steinhoff
, Prof. Dr. med.[AkademischeR BetreuerIn] |
|
136129560 |
|
Universität Rostock, Klinik und Poliklinik für Herzchirurgie |
| Ulrike Gimsa
, Prof. Dr. rer. nat.[AkademischeR BetreuerIn] |
|
Universität Rostock; FBN Dummerstorf, Immunologie |
| Ulrich Martin
, Prof. Dr. rer. nat.[AkademischeR BetreuerIn] |
|
Medizinische Hochschule Hannover, Klinik für Thorax-, Herz- und Gefäßchirurgie |
|
| contributing corporate bodies: |
| Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
|
2147083-2 |
|
| |
| abstract: |
|
Regarding innovative therapeutical approaches for cardiac regeneration, we thoroughly
investigated CD117+ and CD117+AT2R stimulated murine bone marrow stem cells. Electrophysiological
measurements and in vitro results indicated the differentiation into an endothelial-like
phenotype excluding a previously discussed development into cardiomyocytes. Cell implantation
into infarcted murine heart provoked a significant improvement of cardiac function.
AT2R triggered effects were not significantly different and should be analyzed in
interplay with its opposing receptor AT1.
[English] |
|
| document type: |
|
| institution: |
| Faculty of Mathematics and Natural Sciences |
|
| language: |
|
| subject class (DDC): |
| 610 Medical sciences Medicine |
|
| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2015
|
|
| |
| identifiers: |
|
| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000001417 |
| created / modified: |
19.08.2015 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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