The regenerative potential of the CD117+AT2R stimulated cell population in vitro and in vivo

Marion Ludwig

doi:10.18453/rosdok_id00001596

Marion Ludwig

The regenerative potential of the CD117+AT2R stimulated cell population in vitro and in vivo

Universität Rostock, 2015

https://doi.org/10.18453/rosdok_id00001596

Abstract: Regarding innovative therapeutical approaches for cardiac regeneration, we thoroughly investigated CD117+ and CD117+AT2R stimulated murine bone marrow stem cells. Electrophysiological measurements and in vitro results indicated the differentiation into an endothelial-like phenotype excluding a previously discussed development into cardiomyocytes. Cell implantation into infarcted murine heart provoked a significant improvement of cardiac function. AT2R triggered effects were not significantly different and should be analyzed in interplay with its opposing receptor AT1.

Dissertation Freier Zugang

Titel:

The regenerative potential of the CD117+AT2R stimulated cell population in vitro and in vivo

Weitere Titel:

Das regenerative Potential der CD117+AT2R stimulierten Zellpopulation in vitro und in vivo [übersetzt]

Beteiligte Personen:

Marion Ludwig[VerfasserIn]
	1075814340
Gustav Steinhoff , Prof. Dr. med.[AkademischeR BetreuerIn]
	136129560
	Universität Rostock, Klinik und Poliklinik für Herzchirurgie
Ulrike Gimsa , Prof. Dr. rer. nat.[AkademischeR BetreuerIn]
	Universität Rostock; FBN Dummerstorf, Immunologie
Ulrich Martin , Prof. Dr. rer. nat.[AkademischeR BetreuerIn]
	Medizinische Hochschule Hannover, Klinik für Thorax-, Herz- und Gefäßchirurgie

Beteiligte Körperschaften:

Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

Zusammenfassung:

Regarding innovative therapeutical approaches for cardiac regeneration, we thoroughly investigated CD117+ and CD117+AT2R stimulated murine bone marrow stem cells. Electrophysiological measurements and in vitro results indicated the differentiation into an endothelial-like phenotype excluding a previously discussed development into cardiomyocytes. Cell implantation into infarcted murine heart provoked a significant improvement of cardiac function. AT2R triggered effects were not significantly different and should be analyzed in interplay with its opposing receptor AT1. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Mathematisch-Naturwissenschaftliche Fakultät

Sprache:

Englisch

Sachgruppe der DNB:

610 Medizin, Gesundheit

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock

2015