title: |
Molecular, immunological and genetic studies on murine autoimmune pancreatitis |
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contributing persons: |
Farahnaz Asghari[VerfasserIn] |
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1079150099 |
Robert Jaster
, Prof. Dr. med.[AkademischeR BetreuerIn] |
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Universität Rostock, Klinik für Innere Medizin II,Abteilung Gastroenterologie und
Endokrinologie |
Ulrike Gimsa
, Prof. Dr.[AkademischeR BetreuerIn] |
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Universität Rostock, Leibniz-Institut für Nutztierbiologie,Institut für Verhaltensphysiologie,
Dummerstorf |
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contributing corporate bodies: |
Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
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2147083-2 |
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abstract: |
To identify susceptible regions of the genome(quantitative trait loci; QTLs)controlling
Autoimmune pancreatitis in a mouse model of the disease, we established an advanced
intercross line originating from three inbred mouse strains: MRL/MpJ,BXD2,NZM and
wild derived strain Cast. The fourth generation of outbred intercross mice was characterized
phenotypically by scoring histopathological changes of the pancreas and genotyped
(Illumina, USA).Five QTLs, regulating the severity of AIP, were identified, which
mapped to chromosomes 2,4,5 and 6(with Logarithmic P values varied from 3.2 to 5.4).
[English] |
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document type: |
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institution: |
Faculty of Mathematics and Natural Sciences |
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language: |
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subject class (DDC): |
610 Medical sciences Medicine |
570 Life science |
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publication / production: |
Rostock
Rostock: Universität Rostock
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2015
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identifiers: |
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access condition: |
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license/rights statement: |
all rights reserved This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
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RosDok id: |
rosdok_disshab_0000001460 |
created / modified: |
07.12.2015 / 08.08.2023
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metadata license: |
The metadata of this document was dedicated to the public domain (CC0 1.0 Universal Public Domain Dedication). |