Molecular, immunological and genetic studies on murine autoimmune pancreatitis

Farahnaz Asghari

doi:10.18453/rosdok_id00001639

Farahnaz Asghari

Molecular, immunological and genetic studies on murine autoimmune pancreatitis

Universität Rostock, 2015

https://doi.org/10.18453/rosdok_id00001639

Abstract: To identify susceptible regions of the genome(quantitative trait loci; QTLs)controlling Autoimmune pancreatitis in a mouse model of the disease, we established an advanced intercross line originating from three inbred mouse strains: MRL/MpJ,BXD2,NZM and wild derived strain Cast. The fourth generation of outbred intercross mice was characterized phenotypically by scoring histopathological changes of the pancreas and genotyped (Illumina, USA).Five QTLs, regulating the severity of AIP, were identified, which mapped to chromosomes 2,4,5 and 6(with Logarithmic P values varied from 3.2 to 5.4).

Dissertation Freier Zugang

Titel:

Molecular, immunological and genetic studies on murine autoimmune pancreatitis

Beteiligte Personen:

Farahnaz Asghari[VerfasserIn]
	1079150099
Robert Jaster , Prof. Dr. med.[AkademischeR BetreuerIn]
	Universität Rostock, Klinik für Innere Medizin II,Abteilung Gastroenterologie und Endokrinologie
Ulrike Gimsa , Prof. Dr.[AkademischeR BetreuerIn]
	Universität Rostock, Leibniz-Institut für Nutztierbiologie,Institut für Verhaltensphysiologie, Dummerstorf

Beteiligte Körperschaften:

Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

Zusammenfassung:

To identify susceptible regions of the genome(quantitative trait loci; QTLs)controlling Autoimmune pancreatitis in a mouse model of the disease, we established an advanced intercross line originating from three inbred mouse strains: MRL/MpJ,BXD2,NZM and wild derived strain Cast. The fourth generation of outbred intercross mice was characterized phenotypically by scoring histopathological changes of the pancreas and genotyped (Illumina, USA).Five QTLs, regulating the severity of AIP, were identified, which mapped to chromosomes 2,4,5 and 6(with Logarithmic P values varied from 3.2 to 5.4). [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Mathematisch-Naturwissenschaftliche Fakultät

Sprache:

Englisch

Sachgruppe der DNB:

610 Medizin, Gesundheit

570 Biowissenschaften, Biologie

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock