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Aws Mardan Hamdy Al-Abo

Synthesis of functionalized isatins, benzoxazoles, isoflavones, coumarins, by site-selective Suzuki-Miyaura cross-coupling reactions

Universität Rostock, 2015

https://doi.org/10.18453/rosdok_id00001647

Abstract: This thesis includes regioselective palladium catalyzed Suzuki-Miyaura cross coupling reactions of isatins benzoxazols isoflavones and coumarins. These classes of compounds are of pharmacological relevance. Suzuki-Miyaura cross-coupling reactions of dichloro methylindolinen dione afforded arylated isatins. The reactions proceeded with very good site selectivity. The Suzuki-Miyaura reaction of dichlorobenzoxazol, of the bis(triflate) of dihydroxyisoflavone, and of the bis(triflate) of methyl dihydroxycoumarin, with different boronic acids, gave the corresponding site-selective mono-arylated, homo bis-arylated and mixed bis-arylated derivaties, most of them with very good site-selectivity.

doctoral thesis   free access