| title: |
| MicroRNA-based stem cell modifications using magnetic transfection complexes: A non-viral
approach towards cardiac regeneration |
|
| other title: |
| MikroRNA-basierte Stammzellmodifikationen mittels magnetischer Transfektionskomplexe:
Ein nicht-viraler Ansatz für die kardiale Regeneration
[translated]
|
|
| contributing persons: |
| Anna Schade[VerfasserIn] |
 |
108177682X |
| Gustav Steinhoff
, Prof. Dr. med.[AkademischeR BetreuerIn] |
|
136129560 |
|
Universitätsmedizin Rostock, Klinik und Poliklinik für Herzchirurgie |
| Brigitte M. Pützer
, Prof. Dr. med. Dr. rer. nat.[AkademischeR BetreuerIn] |
|
122722388 |
|
Universitätsmedizin Rostock, Institut für Experimentelle Gentherapie und Tumorforschung |
| Stefan Brunner
, PD Dr. med.[AkademischeR BetreuerIn] |
|
Universität München, Medizinische Klinik und Poliklinik I |
|
| contributing corporate bodies: |
| Universität Rostock, Universitätsmedizin[Grad-verleihende Institution] |
|
1029510660 |
|
| |
| abstract: |
|
Regenerative properties of human mesenchymal stem cells (hMSC) can be enhanced by
genetic modifications. Thus we aimed to develop a magnetic non-viral vector for microRNA
(miR) delivery in freshly isolated hMSCs. miR/PEI/MNP transfection showed a better
long term performance compared to miR/PEI transfection. Moreover magnetically modified
hMSCs could be guided by an external magnet contributing to enhanced cell engraftment.
Conclusively a magnetic non-viral carrier for efficient miR delivery in freshly isolated
hMSCs was developed allowing specific control of stem cells and magnetic targeting.
[English] |
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| document type: |
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| institution: |
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| language: |
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| subject class (DDC): |
| 610 Medical sciences Medicine |
|
| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2015
|
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| |
| identifiers: |
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| access condition: |
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| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000001505 |
| created / modified: |
22.12.2015 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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