Identification and characterization of CD4+AT2R+ T cell subpopulation in humans and rats

Anna Skorska

doi:10.18453/rosdok_id00001764

Anna Skorska

Identification and characterization of CD4+AT2R+ T cell subpopulation in humans and rats

Universität Rostock, 2016

https://doi.org/10.18453/rosdok_id00001764

Abstract: The study contributes to the understanding of CD4+AT2R+ cell function after myocardial infarction (MI). This potential novel T cell subset, which expresses FoxP3 and various cytokines improves cardiac function and reduces infarct size. Results indicate that the CD4+AT2R+ T cells might be included in therapeutic approaches for the treatment of cardiac diseases, due to its upregulation in the infarcted state. The application of this T cell subset may improve the healing process of compromised heart tissue and contribute to a better quality of life in affected patients.

Dissertation Freier Zugang

Titel:

Identification and characterization of CD4+AT2R+ T cell subpopulation in humans and rats

Weitere Titel:

Identifizierung und Charakterisierung der CD4+AT2R+ T Zell Subpopulation bei Mensch und Ratte [übersetzt]

Beteiligte Personen:

Anna Skorska[VerfasserIn]
	1105676196
Gustav Steinhoff , Prof. Dr. med.[AkademischeR BetreuerIn]
	136129560
	Rostock University Medical Center, Clinic and Policlinic for Cardiac Surgery
Brigitte Vollmar , Prof. Dr. med.[AkademischeR BetreuerIn]
	136319564
	Rostock University Medical Center, Institute for Experimental Surgery
Hans-Dieter Volk , Prof. Dr. med.[AkademischeR BetreuerIn]
	Charité – Universitätsmedizin Berlin, Institute of Medical Immunology; Berlin-Brandenburger Center for Regenerative Therapies (BCRT)

Beteiligte Körperschaften:

Universität Rostock, Universitätsmedizin[Grad-verleihende Institution]
	1029510660

Zusammenfassung:

The study contributes to the understanding of CD4+AT2R+ cell function after myocardial infarction (MI). This potential novel T cell subset, which expresses FoxP3 and various cytokines improves cardiac function and reduces infarct size. Results indicate that the CD4+AT2R+ T cells might be included in therapeutic approaches for the treatment of cardiac diseases, due to its upregulation in the infarcted state. The application of this T cell subset may improve the healing process of compromised heart tissue and contribute to a better quality of life in affected patients. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Universitätsmedizin

Sprache:

Englisch

Sachgruppe der DNB:

610 Medizin, Gesundheit

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock

2016