Caveolae-mediated phagocytosis of biomaterial surface structures by human osteoblasts

Caroline Mörke

doi:10.18453/rosdok_id00001785

Caroline Mörke

Caveolae-mediated phagocytosis of biomaterial surface structures by human osteoblasts

Universität Rostock, 2016

https://doi.org/10.18453/rosdok_id00001785

Abstract: Cells are sensitive to their underlying topography, which evoke large ranges of cell responses. The work describes an attempted caveolae-mediated phagocytosis of the surface-fixed micro-pillars by human MG-63 osteoblastic cells. This attempt to phagocytize the elevations of the Ti surface results in higher energy requirements for the cells and finally to impaired osteoblast function. Similar cell responses were observed for the osteoblasts treated with micro-particles as phagocytosis trigger and osteoblasts growing on stochastic rough Ti surfaces, commercially used as implant surfaces.

Dissertation Freier Zugang

Titel:

Caveolae-mediated phagocytosis of biomaterial surface structures by human osteoblasts

Beteiligte Personen:

Caroline Mörke[VerfasserIn]
	1111521808
Barbara Nebe , Prof. Dr.[AkademischeR BetreuerIn]
	172943744
	Universitätsmedizin Rostock, Zentrum für Medizinische Forschung, Arbeitsbereich Zellbiologie
Sergei A. Kuznetsov , PD Dr.[AkademischeR BetreuerIn]
	Universität Rostock, Institut für Biowissenschaften, Abteilung Tierphysiologie
Jan de Boer , Prof. Dr.[AkademischeR BetreuerIn]
	University of Twente, Institute for Biomedical Technology and Technical Medicine

Beteiligte Körperschaften:

Universität Rostock, Universitätsmedizin[Grad-verleihende Institution]
	1029510660

Zusammenfassung:

Cells are sensitive to their underlying topography, which evoke large ranges of cell responses. The work describes an attempted caveolae-mediated phagocytosis of the surface-fixed micro-pillars by human MG-63 osteoblastic cells. This attempt to phagocytize the elevations of the Ti surface results in higher energy requirements for the cells and finally to impaired osteoblast function. Similar cell responses were observed for the osteoblasts treated with micro-particles as phagocytosis trigger and osteoblasts growing on stochastic rough Ti surfaces, commercially used as implant surfaces. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Universitätsmedizin

Sprache:

Englisch

Sachgruppe der DNB:

570 Biowissenschaften, Biologie

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock

2016