Unraveling the transcriptional Cis-regulatory code

Leila Taher

doi:10.18453/rosdok_id00001799

Leila Taher Dr.

Unraveling the transcriptional Cis-regulatory code

Universität Rostock, 2016

https://doi.org/10.18453/rosdok_id00001799

Abstract: It is nowadays accepted that eukaryotic complexity is not dictated by the number of protein-coding genes of the genome, but rather achieved through the combinatorics of gene expression programs. Distinct aspects of the expression pattern of a gene are mediated by discrete regulatory sequences, known as cis-regulatory elements. The work described in this thesis was aimed at developing computational and statistical methods to guide the search and characterization of novel cis-regulatory elements.

Dissertation Freier Zugang

Titel:

Unraveling the transcriptional Cis-regulatory code

Beteiligte Personen:

Leila Taher , Dr.[VerfasserIn]
	111215731X
Wojciech Makalowski , Prof. Dr.[AkademischeR BetreuerIn]
	Westfälische Wilhelms-Universität Münster, Institut für Bioinformatik
Burkhard Morgenstern , Prof. Dr.[AkademischeR BetreuerIn]
	Georg-August-Universität Göttingen, Institut für Mikrobiologie und Genetik
Georg Füllen , Prof. Dr.[AkademischeR BetreuerIn]
	140626085
	Universitätsmedizin Rostock, Institut für Biostatistik und Informatik in Medizin und Alterns- forschung

Beteiligte Körperschaften:

Universität Rostock, Universitätsmedizin[Grad-verleihende Institution]
	1029510660

Zusammenfassung:

It is nowadays accepted that eukaryotic complexity is not dictated by the number of protein-coding genes of the genome, but rather achieved through the combinatorics of gene expression programs. Distinct aspects of the expression pattern of a gene are mediated by discrete regulatory sequences, known as cis-regulatory elements. The work described in this thesis was aimed at developing computational and statistical methods to guide the search and characterization of novel cis-regulatory elements. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Universitätsmedizin

Sprache:

Englisch

Sachgruppe der DNB:

570 Biowissenschaften, Biologie

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock

2016