goto contents

Thomas Schöppe

Bioinformatische Analyse immunmodulatorischer Prozesse in LEW.1AR1-iddm Ratten - einem Rattenmodell des Autoimmundiabetes

Universität Rostock, 2016

Abstract: The LEW.1AR1-iddm rat animal model develops a autoimmune diabetes (T1DM) with beta cell destruction. Aim of this study: Investigation of predictive potential of gene expression profiling in peripheral blood and tolerance-inducing effects through treatment by the modulating antibody RIB5/2 in the prediabetic period. Results were, inflammatory gene expression profiles in PBMCs may serve as surrogate markers for different stages of islet inflammation in T1DM. Diabetes preventing antibody RIB5/2 treatment could induce tolerance against beta cell autoimmunity with specific gene signatures in blood.

doctoral thesis   free access    


OPACGVKDataCite Commons


all rights reserved

This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz).