Universität Rostock, 2017
Abstract: The objective of this work was the analysis of the clinical and paraclinic course of the disease as well as the analysis of dynamic transcriptional effects in peripheral blood mononuclear cells of 25 MS-patients treated with IFN-β-1b. Thus, the long-term therapeutic response to IFN-β-1b therapy as well as the underlying molecular mechanisms of action should be elucidated. In addition, an association analysis of the clinical and molecular biology results should show prognostic biomarker candidates.
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