goto contents

Ole Kandulski

Analyse des klinischen und paraklinischen Verlaufs sowie der Genexpressionsveränderungen von Multiple Sklerose Patienten unter Interferon-β-1b-Therapie

Universität Rostock, 2017

Abstract: The objective of this work was the analysis of the clinical and paraclinic course of the disease as well as the analysis of dynamic transcriptional effects in peripheral blood mononuclear cells of 25 MS-patients treated with IFN-β-1b. Thus, the long-term therapeutic response to IFN-β-1b therapy as well as the underlying molecular mechanisms of action should be elucidated. In addition, an association analysis of the clinical and molecular biology results should show prognostic biomarker candidates.

doctoral thesis   free access    


OPACGVKDataCite Commons


all rights reserved

This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz).