| title: |
| Magnetic nanoparticle-based gene delivery: mechanisms and clinical perspectives |
|
| other title: |
| Magnetische Nanopartikel-basierter Gentransfer: Mechanismen und Klinische Perspektiven
[translated]
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| contributing persons: |
| Evgenya Delyagina[VerfasserIn] |
 |
1128603144 |
| Gustav Steinhoff
, Prof. Dr. med.[AkademischeR BetreuerIn] |
|
136129560 |
|
Universitätsmedizin Rostock, Klinik und Poliklinik für Herzchirurgie |
| Brigitte M. Pützer
, Prof. Dr. med. Dr. rer. nat.[AkademischeR BetreuerIn] |
|
122722388 |
|
Universitätsmedizin Rostock, Institut für Experimentelle Gentherapie und Tumorforschung |
| Martin Zenke
, Prof. Dr. rer. nat.[AkademischeR BetreuerIn] |
|
1082299979 |
|
RWTH Aachen, Universitätsklinikum der RWTH, Helmholtz-Institut für Biomedizinische
Technik |
|
| contributing corporate bodies: |
| Universität Rostock, Universitätsmedizin[Grad-verleihende Institution] |
|
1029510660 |
|
| |
| abstract: |
|
The development of safe and efficient gene delivery systems is the key to the overall
success of gene therapy. This work introduced a MNP-based nonviral gene delivery approach
for transfection in clinically relevant cells. Moreover, the in vitro mechanism studies
could explained the beneficial properties of the proposed carrier design. This work
demonstrated, that proposed system could efficiently and safely transfect human bone
marrow derived mesenchymal stem cells. Additionaly, the clinical perspectives of MNP-based
gene therapy were discussed and evaluated in this dissertation.
[English] |
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| document type: |
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| institution: |
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| language: |
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| subject class (DDC): |
| 610 Medical sciences Medicine |
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| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2017
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| identifiers: |
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| access condition: |
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| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
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| RosDok id: |
rosdok_disshab_0000001696 |
| created / modified: |
27.03.2017 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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