Magnetic nanoparticle-based gene delivery : mechanisms and clinical perspectives

Evgenya Delyagina

doi:10.18453/rosdok_id00001874

Evgenya Delyagina

Magnetic nanoparticle-based gene delivery : mechanisms and clinical perspectives

Universität Rostock, 2017

https://doi.org/10.18453/rosdok_id00001874

Abstract: The development of safe and efficient gene delivery systems is the key to the overall success of gene therapy. This work introduced a MNP-based nonviral gene delivery approach for transfection in clinically relevant cells. Moreover, the in vitro mechanism studies could explained the beneficial properties of the proposed carrier design. This work demonstrated, that proposed system could efficiently and safely transfect human bone marrow derived mesenchymal stem cells. Additionaly, the clinical perspectives of MNP-based gene therapy were discussed and evaluated in this dissertation.

Dissertation Freier Zugang

title:

Magnetic nanoparticle-based gene delivery: mechanisms and clinical perspectives

other title:

Magnetische Nanopartikel-basierter Gentransfer: Mechanismen und Klinische Perspektiven [translated]

contributing persons:

Evgenya Delyagina[VerfasserIn]
	1128603144
Gustav Steinhoff , Prof. Dr. med.[AkademischeR BetreuerIn]
	136129560
	Universitätsmedizin Rostock, Klinik und Poliklinik für Herzchirurgie
Brigitte M. Pützer , Prof. Dr. med. Dr. rer. nat.[AkademischeR BetreuerIn]
	122722388
	Universitätsmedizin Rostock, Institut für Experimentelle Gentherapie und Tumorforschung
Martin Zenke , Prof. Dr. rer. nat.[AkademischeR BetreuerIn]
	1082299979
	RWTH Aachen, Universitätsklinikum der RWTH, Helmholtz-Institut für Biomedizinische Technik

contributing corporate bodies:

Universität Rostock, Universitätsmedizin[Grad-verleihende Institution]
	1029510660

abstract:

The development of safe and efficient gene delivery systems is the key to the overall success of gene therapy. This work introduced a MNP-based nonviral gene delivery approach for transfection in clinically relevant cells. Moreover, the in vitro mechanism studies could explained the beneficial properties of the proposed carrier design. This work demonstrated, that proposed system could efficiently and safely transfect human bone marrow derived mesenchymal stem cells. Additionaly, the clinical perspectives of MNP-based gene therapy were discussed and evaluated in this dissertation. [Englisch]

document type:

Dissertation

institution:

Universitätsmedizin

language:

Englisch

subject class (DDC):

610 Medizin, Gesundheit

publication /
production:

Rostock: Universität Rostock

2017

identifiers: