Oral bacteria, stem cells and neutrophils in vitro : a model for periodontal infection

Cathleen Hieke

doi:10.18453/rosdok_id00001941

Cathleen Hieke

Oral bacteria, stem cells and neutrophils in vitro : a model for periodontal infection

Universität Rostock, 2017

https://doi.org/10.18453/rosdok_id00001941

Abstract: Periodontitis is a chronic inflammatory disease induced by bacteria from oral biofilms. Bacteria interact with host cells and can subsequently provoke activation of polymorphonuclear neutrophils (PMNs). In this study, an in vitro model was applied to investigate interactions between periodontal pathogens, i.e., P. intermedia, T. forsythia and P. gingivalis, human dental stem cells (hDFSCs) and PMNs. HDFSCs modulate immune activity of PMNs after infection with oral bacteria implying general suitability of hDFSCs in tissue regeneration strategies after tissue damage in periodontal infections.

Dissertation Freier Zugang

Titel:

Oral bacteria, stem cells and neutrophils in vitro: a model for periodontal infection

Beteiligte Personen:

Cathleen Hieke[VerfasserIn]
	1136984550
Bernd Kreikemeyer , Prof. Dr. rer. nat.[AkademischeR BetreuerIn]
	114684618
	Universität Rostock, Institut für Mikrobiologie, Virologie und Hygiene
Hubert Bahl , Prof. Dr. rer. nat.[AkademischeR BetreuerIn]
	132475170
	Universität Rostock, Institut für Mikrobiologie, Virologie und Hygiene

Beteiligte Körperschaften:

Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

Zusammenfassung:

Periodontitis is a chronic inflammatory disease induced by bacteria from oral biofilms. Bacteria interact with host cells and can subsequently provoke activation of polymorphonuclear neutrophils (PMNs). In this study, an in vitro model was applied to investigate interactions between periodontal pathogens, i.e., P. intermedia, T. forsythia and P. gingivalis, human dental stem cells (hDFSCs) and PMNs. HDFSCs modulate immune activity of PMNs after infection with oral bacteria implying general suitability of hDFSCs in tissue regeneration strategies after tissue damage in periodontal infections. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Mathematisch-Naturwissenschaftliche Fakultät

Sprache:

Englisch

Sachgruppe der DNB:

570 Biowissenschaften, Biologie

Veröffentlichung /
Entstehung:

Rostock: Universität Rostock

2017

Identifikatoren: