Adhesive mechanisms of histone-induced neutrophil-endothelium interactions in the muscle microcirculation

Johanna Pügge

doi:10.18453/rosdok_id00002004

Johanna Pügge

Adhesive mechanisms of histone-induced neutrophil-endothelium interactions in the muscle microcirculation

Universität Rostock, 2017

https://doi.org/10.18453/rosdok_id00002004

Abstract: Intravital microscopy of the mouse cremaster microcirculation was used to examine the role of specific adhesion molecules in histone-dependent leukocyte recruitment. Histones type 3 were given locally to the cremaster muscle sack and specific adhesion molecules were blocked by systemic administration of monoclonal antibodies. Extracellular histones 3 induced leukocyte recruitment in a dose-dependent manner. Histone-induced neutrophil rolling is predominately mediated by P-selectin/PSGL-1 interactions, whereas histone-induced leukocyte adhesion is inter alia mediated by Mac-1 and LFA-1.

Dissertation Freier Zugang

Titel:

Adhesive mechanisms of histone-induced neutrophil-endothelium interactions in the muscle microcirculation

Beteiligte Personen:

Johanna Pügge[VerfasserIn]
	1149269332
Brigitte Vollmar , Prof. Dr. med.[AkademischeR BetreuerIn]
	136319564
	Universitätsmedizin Rostock, Institut für Experimentelle Chirurgie
Henrik Thorlacius , Prof. Dr. med.[AkademischeR BetreuerIn]
	Lund University, Department of Clinical Science, Surgery Research Unit
Ernst Klar , Prof. Dr. med.[AkademischeR BetreuerIn]
	136455107
	Universitätsmedizin Rostock, Abteilung für Allgemeine, Thorax-, Gefäß-, und Transplantationschirurgie,

Beteiligte Körperschaften:

Universität Rostock, Universitätsmedizin[Grad-verleihende Institution]
	1029510660

Zusammenfassung:

Intravital microscopy of the mouse cremaster microcirculation was used to examine the role of specific adhesion molecules in histone-dependent leukocyte recruitment. Histones type 3 were given locally to the cremaster muscle sack and specific adhesion molecules were blocked by systemic administration of monoclonal antibodies. Extracellular histones 3 induced leukocyte recruitment in a dose-dependent manner. Histone-induced neutrophil rolling is predominately mediated by P-selectin/PSGL-1 interactions, whereas histone-induced leukocyte adhesion is inter alia mediated by Mac-1 and LFA-1. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Universitätsmedizin

Sprache:

Englisch

Sachgruppe der DNB:

610 Medizin, Gesundheit

Veröffentlichung /
Entstehung:

Rostock: Universität Rostock

2017

Identifikatoren: