Palladium-catalyzed synthesis of pyrrole-, indole- and phenanthridine-fused polycyclic aromatic compounds from ortho-dihaloarenes

Ngo Nghia Pham

doi:10.18453/rosdok_id00002047

Ngo Nghia Pham

Palladium-catalyzed synthesis of pyrrole-, indole- and phenanthridine-fused polycyclic aromatic compounds from ortho-dihaloarenes

Universität Rostock, 2018

https://doi.org/10.18453/rosdok_id00002047

Abstract: Convenient palladium-catalyzed syntheses of polycyclic nitrogen heterocycles from ortho-dihaloarenes were developed. First, syntheses of pyrrole-fused derivatives via domino C-C/C-N coupling of ortho-dihaloarenes with imines were accomplished. Employment of ortho-dihaloarenes for sequential regioselective Suzuki reaction/double C-N coupling afforded corresponding indole-fused structures. Finally, syntheses of previously unexplored phenanthridine-fused architectures by regioselective Sonogashira reaction followed by domino or one-pot C-N coupling/hydroamination/C-H arylation were described.

Dissertation Freier Zugang

Titel:

Palladium-catalyzed synthesis of pyrrole-, indole- and phenanthridine-fused polycyclic aromatic compounds from ortho-dihaloarenes

Beteiligte Personen:

Ngo Nghia Pham[VerfasserIn]
	1127072730
Peter Langer , Prof. Dr. Dr. h. c. mult.[AkademischeR BetreuerIn]
	132314614
	Universität Rostock, Institut für Chemie
Andreas Schmidt , apl. Prof. Dr. rer. nat. habil.[AkademischeR BetreuerIn]
	13280252X
	Universität Clausthal, Institut für Organische Chemie

Beteiligte Körperschaften:

Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

Zusammenfassung:

Convenient palladium-catalyzed syntheses of polycyclic nitrogen heterocycles from ortho-dihaloarenes were developed. First, syntheses of pyrrole-fused derivatives via domino C-C/C-N coupling of ortho-dihaloarenes with imines were accomplished. Employment of ortho-dihaloarenes for sequential regioselective Suzuki reaction/double C-N coupling afforded corresponding indole-fused structures. Finally, syntheses of previously unexplored phenanthridine-fused architectures by regioselective Sonogashira reaction followed by domino or one-pot C-N coupling/hydroamination/C-H arylation were described. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Mathematisch-Naturwissenschaftliche Fakultät

Sprache:

Englisch

Sachgruppe der DNB:

540 Chemie

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock

2018