title: |
Production and characterization of genetically modified magnetized cells for future
targeted treatment of cardiovascular diseases |
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contributing persons: |
Natalia Voronina[VerfasserIn] |
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1155939417 |
Alexander Pfeifer
, Prof. Dr.[AkademischeR BetreuerIn] |
 |
1068472898 |
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Universitätsklinikum Bonn, Institut für Pharmakologie und Toxikologie |
Robert David
, Prof. Dr.[AkademischeR BetreuerIn] |
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Unversitätsmedizin Rostock, Referenz-und Translationszentrum für Kardiale Stammzelltherapie |
Michael O. Glocker
, Prof. Dr.[AkademischeR BetreuerIn] |
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Unversitätsmedizin Rostock, Proteomzentrum |
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contributing corporate bodies: |
Universität Rostock, Universitätsmedizin[Grad-verleihende Institution] |
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1029510660 |
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abstract: |
Gene therapy is a promising tool for cardiovascular disease treatment. Its wide clinical
application is, however, limited by the lack of suitable targeted gene delivery systems.
In this work, a non-viral vector was tested - composed by polyethyleneimine and magnetic
nanoparticles (PEI/MNP) - with primary endothelial cells as in vitro model for angiogenesis
and CD133+ hematopoietic stem cells. The obtained results indicate that transient
genetic modification of cells with miRNA delivered by PEI/MNP is feasible and results
in their magnetization sufficient for targeting and MRI detection.
[English] |
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document type: |
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institution: |
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language: |
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subject class (DDC): |
610 Medical sciences Medicine |
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publication / production: |
Rostock
Rostock: Universität Rostock
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2018
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identifiers: |
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access condition: |
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license/rights statement: |
all rights reserved This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
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RosDok id: |
rosdok_disshab_0000001878 |
created / modified: |
11.04.2018 / 08.08.2023
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metadata license: |
The metadata of this document was dedicated to the public domain (CC0 1.0 Universal Public Domain Dedication). |