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Die vorliegende Arbeit beschreibt die Synthese von Thieno[3,2-b]indolen, Pyrrolo[1,2
a][1,8]naphthyridinen, Pyrrolo[1,2-a][1,6]naphthyridinen sowie Indolizino[6,5,4,3-ija][1,6]naphthyridinen.
Zum Aufbau der polycyclischen Systeme wurden vorwiegend Palladium-katalysierte Kupplungsreaktionen
(Suzuki Reaktion, Sonogashira Reaktion, Buchwald-Hartwig-Kupplung) sowie Cycloisomerisierungs-Reaktionen
(Ringschluss Alkin-Carbonyl-Metathese, intramolekulare elektrophile aromatische Substitution)
verwendet.
[German] |
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The present thesis deals with the synthesis of thieno[3,2-b]indoles, pyrrolo[1,2-a][1,8]naphthyridines,
pyrrolo[1,2-a][1,6]naphthyridines as well as indolizino[6,5,4,3-ija][1,6]naphthyridines.
All starting materials are easy available building-blocks. To prepare the polycyclic
compounds, especially palladium-catalyzed cross-coupling reactions (Suzuki reaction,
Sonogashira reaction, Buchwald-Hartwig amination) and cycloisomerization reactions
(ring-closing alkyne-carbonyl-metathesis, intramolecular electrophilic aromatic substitution)
were used.
[English] |
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