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Helena Apelt

Potential intermediates for antiviral and antitumor agents

Universität Rostock, 2018

Abstract: In this work, potential intermediates for antiviral and antitumor agents were successfully synthesized. This thesis is focused on the development of the 2-deoxy-D-ribofuranose analogues, due to the similarity with DNA building blocks, with diamine moieties that should be able to form metal complexes similar to cisplatin. This thesis deals with the synthesis and characterization of C-nucleoside analogues of D-ribose. In addition, we have succeeded in obtaining several 2-deoxy-D-ribofuranose derivatives with ethylenediamine group on a spacer with one or three carbon atoms to the sugar moiety.

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