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Stefan Jopp

Funktionalisierung von antikoagulativen und estrogenen Wirk- und Naturstoffen

Universität Rostock, 2018

Abstract: A new drug release system based on tosylated dabigatran, a self-immolative linker and the amino acid L-arginine was developed. These new compounds were positively tested for their coagulation-inhibiting properties. Furthermore estrone was functionalized using the palladium catalyzed Suzuki-Miyaura reaction. Several new mono- and bisarylated estrones (in the positions 2, 3, 4 or 17) were synthesized using chemoselective and regioselective methods.

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