| title: |
| Synthesis of functionalized heterocycles via palladium catalyzed cross-coupling reactions |
|
| contributing persons: |
|
| contributing corporate bodies: |
| Universität Rostock[Grad-verleihende Institution] |
 |
38329-6 |
| Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
|
2147083-2 |
|
| |
| abstract: |
|
This present thesis is dedicated to the design and the synthesis of novel biologically
active and fluorescent heterocycles from common starting materials. Based on Palldium(0)
catalyzed reactions, a series of new ethynylated naphthalenes, ethynylated naphthaleneindoles,
benzo[b]carbazolediones, benzofuroindoles and furodiindoles were synthesized with
high yield. Synthesized compounds show interesting fluorescence properties with high
quantum yields (19-78%). The benzocarbazolediones can be used as selective inhibitors
against nucleotide pyrophosphatase.
[English] |
|
Die vorliegende Dissertation widmet sich der Synthese von neuen, biologisch aktiven
bzw. fluoreszierenden Heterozyklen, ausgehend von leicht zugänglichen Ausgangsstoffen.
Durch Anwendung von Palladium(0) katalysierten Kupplungsreaktionen wurden verschiedene
alkynylierte Naphthalenindole und Benzocarbazoldione sowie verschiedene Furoindole
hergestellt. Die synthetisierten Verbindungen zeigen interessante Fluoreszenzeigenschaften
wie z.B. hohe Quantenausbeuten (19-78%). Außerdem wurden die Benzocarbazoldione bezüglich
ihrer Aktivität gegen verschiedene Nukleotid Pyrophosphatasen untersucht.
[German] |
|
| document type: |
|
| institution: |
| Faculty of Mathematics and Natural Sciences |
|
| language: |
|
| subject class (DDC): |
| 540 Chemistry & allied sciences |
|
| |
publication /
production: |
|
Rostock: Universität Rostock
|
|
2017
|
|
| statement of responsibility: |
| vorgelegt von Huy Hoang Do |
|
| |
| identifiers: |
|
| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000002007 |
| created / modified: |
06.12.2018 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
access
viewer
fulltext