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Robert Bestel

Simulation neuronaler Aktionspotentiale in Hinblick auf Zellform und Physiologie sowie deren Ableitung mittels extrazellulärer Mikroelektroden

Universität Rostock, 2018

Abstract: In order to investigate the cause for the variety signal shapes present in extracellular measurements of neuronal activity, a detailed neuron model based on the finite element method is created. In a simulation study the impact of geometrical and electrophysiological properties of the neuron as well as several parameters of the neuron-electrode coupling on the derived signal shape is analyzed. Results show a significant dependence of the signal shape on the position of the recording electrode as well as a noticeable influence of the cell-electrode coupling on the signal amplitude.

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