Universität Rostock, 2018
Abstract: This is a concept study of designing two contraceptive vaccines, expressing them in different plant expression systems und testing their efficacy. As antigens fertilization-relevant Zona Pellucida proteins were used. Stable transformed pea seeds, tobacco seeds, tobacco leaves and carrot cells show vaccine accumulation. A transient expression system was used for producing and characterizing the vaccines. The vaccines elicited a strong immune response, which reduced offspring of BALB/c mice up to 52 %.
doctoral thesis free access