Universität Rostock, 2018
Abstract: Infection with the intravascular diecious trematode Schistosoma spp. remains a serious tropical disease and public health problem in the developing world, affecting over 258 million people worldwide. The suppression of protective host immune mechanisms by helminths promotes parasite survival and benefits the host by reducing tissue damage. This study is the first to show that female schistosomes suppress early innate immune responses to invading cercariae in the skin and upregulate anergy-associated genes.
doctoral thesis free access