| title: |
| Differentiation and survival of human neural progenitor cells in 3D scaffolds of self-assembling
peptide hydrogels |
|
| contributing persons: |
| Andrea Liedmann[VerfasserIn] |
 |
1191293580 |
| Arndt Rolfs[AkademischeR BetreuerIn] |
|
136256864 |
| Sergei A. Kuznetsov[AkademischeR BetreuerIn] |
| Andreas Wree[AkademischeR BetreuerIn] |
|
136643280 |
|
| contributing corporate bodies: |
| Universität Rostock[Grad-verleihende Institution] |
|
38329-6 |
| Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
|
2147083-2 |
|
| |
| abstract: |
|
In this project we used a human neural progenitor cell line (hNPCs), whereat the cells
were embedded in the synthetic self-assembling peptide hydrogel and modified formulations.
Different protocols of culture conditions (2D versus 3D) were compared to analyze
the neuronal differentiation and survival of the cells. The hydrogels enhance the
neuronal differentiation of the hNPCs of about 2.3 fold, with an additional increase
of about 2,5 fold more for the modified Scaffolds. Additionally the hNPCs were protected
from apoptosis and accordingly survived longer when encapsulated in 3D scaffolds.
[English] |
|
| document type: |
|
| institution: |
| Faculty of Mathematics and Natural Sciences |
|
| language: |
|
| subject class (DDC): |
| 570 Life science |
| 610 Medical sciences Medicine |
|
| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2013
|
|
| statement of responsibility: |
| vorgelegt von Andrea Liedmann |
|
| |
| identifiers: |
|
| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000002146 |
| created / modified: |
24.07.2019 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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