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Philipp Alexander Wysotzki

Betrachtung von Einflüssen auf die initialen Zelladhäsionskräfte mittels Einzelzellkraftspektroskopie

Universität Rostock, 2019

Abstract: In this thesis the detachment forces of different eukaryotic and prokaryotic cells were investigated by single cell force spectroscopy (SCFS). It could be shown that in the first phase of the initial adhesion the unspecific interactions between surface and cell were the determining factor. In contrast, the FluidFM experiments for mature cell adhesion showed higher detachment forces on cell type-specific coated surfaces. In addition, a positive influence of an alkaline pH value on the initial adhesion of osteoblasts was demonstrated.

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