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Yvonne Wollank

Untersuchungen zum Einfluss von Fettsäureamidohydrolase-Hemmstoffen auf die Migration und Differenzierung humaner Stammzellen

Universität Rostock, 2019

Abstract: Inhibition of FAAH results in reduced degradation and therefore increased effects of cannabinoids. FAAH inhibitors were found to increase the migration of ADSCs. FAAH substrates mimicked the promigratory action of FAAH inhibitors. Promigratory effects of FAAH inhibitors and substrates were causally linked to activation of p42/44 MAPKs, as well as PPARα: FAAH inhibitors and substrates cause p42/44 MAPK phosphorylation, which subsequently activates PPARα to confer increased migration of MSCs. Additionally it could be demonstrated that FAAH inhibitors induce osteogenesis.

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