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Anne Bohl

Entwicklung von antiproliferativ und neurotroph wirkenden Poly(dimethylsiloxan)-Oberflächen zur Verbesserung der Langzeitfunktionalität von Cochlea-Implantaten

Universität Rostock, 2019

Abstract: Poly (dimethylsiloxane) (PDMS) is used as a carrier material for cochlear implants. PDMS is limited in its biocompatibility. Active ingredients are used to suppress connective tissue growth at the PDMS surface. A PDMS surface modification is investigated to allow a drug-containing polymer matrix. Another purpose of the work is the targeted release of the biomolecule brain-derived neurotrophic factor (BDNF). BDNF stimulate the ganglion cells that are important for hearing. The release of DMS and BDNF was followed by a quasi-stationary model.

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