Molecular recognition studies by nanoESI mass spectrometry

Bright D. Danquah

doi:10.18453/rosdok_id00002661

Bright D. Danquah

Molecular recognition studies by nanoESI mass spectrometry

Universität Rostock, 2019

https://doi.org/10.18453/rosdok_id00002661

Abstract: Analytical methods that characterize antibody-antigen interactions are certainly worth developing as they illuminate our understanding of molecular mechanisms of certain disease processes, and ultimately provide opportunities to improve existing treatment and management of such diseases by designing novel therapeutics. In this thesis, the challenges associated with the existing methods have been surpassed by developing simple but accurate nanoESI mass spectrometry methods which can be used to characterize antibody specificities as well as estimation of their binding affinities.

Dissertation Freier Zugang

Titel:

Molecular recognition studies by nanoESI mass spectrometry

Beteiligte Personen:

Bright D. Danquah[VerfasserIn]
	0000-0002-6990-8434
	1209277859
Michael Glocker[AkademischeR BetreuerIn]
	0000-0001-9190-482X
	1014052165
Christopher Gerner[AkademischeR BetreuerIn]
Georg Füllen[AkademischeR BetreuerIn]
	140626085

Beteiligte Körperschaften:

Universität Rostock[Grad-verleihende Institution]
	38329-6
Universitätsmedizin Rostock[Grad-verleihende Institution]
	1029510660

Zusammenfassung:

Analytical methods that characterize antibody-antigen interactions are certainly worth developing as they illuminate our understanding of molecular mechanisms of certain disease processes, and ultimately provide opportunities to improve existing treatment and management of such diseases by designing novel therapeutics. In this thesis, the challenges associated with the existing methods have been surpassed by developing simple but accurate nanoESI mass spectrometry methods which can be used to characterize antibody specificities as well as estimation of their binding affinities. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Universitätsmedizin

Sprache:

Englisch

Sachgruppe der DNB:

500 Naturwissenschaften

610 Medizin, Gesundheit

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock