| title: |
| Transcription factor properties of ZNF746 and ZNF777 with focus on their domains of
unknown function 3669 (DUF3669) |
|
| contributing persons: |
| Mohannad Al Chiblak[VerfasserIn] |
 |
1221081209 |
| Markus Tiedge[AkademischeR BetreuerIn] |
|
13860231X |
| Hans-Jürgen Thiesen[AkademischeR BetreuerIn] |
|
136714013 |
| Christian Sina[AkademischeR BetreuerIn] |
|
128924594 |
|
| contributing corporate bodies: |
| Universität Rostock[Grad-verleihende Institution] |
|
38329-6 |
| Universitätsmedizin Rostock[Grad-verleihende Institution] |
|
1029510660 |
|
| |
| abstract: |
|
This study evaluates the repression activities of two DUF3669-containing KRAB-ZNF
proteins; ZNF746 and ZNF777 in addition to the oligomerizing ability of their domain
of unknown function (DUF3669). A new domain model for DUF3669 has been established
in this study. DUF3669 as an oligomerizing domain was confirmed in our study. Our
data revealed the adding functionalities for the repression activities of ZNF746;
DUF3669 as an oligomerizing domain might recruit other DUF3669-KRAB-ZNF proteins and
the SUMOylation might stabilize the repression complex and directly recruit chromatin
modifiers.
[English] |
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| document type: |
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| institution: |
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| language: |
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| subject class (DDC): |
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publication /
production: |
Rostock
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Rostock: Universität Rostock
|
|
2020
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|
| statement of responsibility: |
| vorgelegt von Mohannadd Al Chiblak |
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| identifiers: |
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| access condition: |
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| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
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| RosDok id: |
rosdok_disshab_0000002374 |
| created / modified: |
09.11.2020 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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