Proteome profiling of maternal serum : a novel approach for intrauterine growth restriction screening during pregnancy

Charles Ayensu Okai

doi:10.18453/rosdok_id00002801

Charles Ayensu Okai

Proteome profiling of maternal serum : a novel approach for intrauterine growth restriction screening during pregnancy

Universität Rostock, 2020

https://doi.org/10.18453/rosdok_id00002801

Abstract: Fetal growth restriction affects pregnancies leading to perinatal mortality and morbidity. Current diagnostic method is by ultrasound inspection but cannot differentiate SGA fetuses from IUGR fetuses. Maternal serum from IUGR, SGA and control pregnant women were analysed using affinity-mass spectrometry. Separation confidence reached a sensitivity of 0.90, specificity of 0.79 with an area under curve of 0.88 in receiver operator characteristics. Proteome profiling by affinity-mass spectrometry during pregnancy provides a reliable method for risk assessment of impaired development in fetuses.

Dissertation Freier Zugang

Titel:

Proteome profiling of maternal serum: a novel approach for intrauterine growth restriction screening during pregnancy

Beteiligte Personen:

Charles Ayensu Okai[VerfasserIn]
	1221141015
Michael Glocker[AkademischeR BetreuerIn]
	0000-0001-9190-482X
	1014052165
Ulrich Pecks[AkademischeR BetreuerIn]
	0000-0002-0784-1262
	132141809
Hugo Istvan Murua Escobar[AkademischeR BetreuerIn]
	12980455X

Beteiligte Körperschaften:

Universität Rostock[Grad-verleihende Institution]
	38329-6
Universitätsmedizin Rostock[Grad-verleihende Institution]
	1029510660

Zusammenfassung:

Fetal growth restriction affects pregnancies leading to perinatal mortality and morbidity. Current diagnostic method is by ultrasound inspection but cannot differentiate SGA fetuses from IUGR fetuses. Maternal serum from IUGR, SGA and control pregnant women were analysed using affinity-mass spectrometry. Separation confidence reached a sensitivity of 0.90, specificity of 0.79 with an area under curve of 0.88 in receiver operator characteristics. Proteome profiling by affinity-mass spectrometry during pregnancy provides a reliable method for risk assessment of impaired development in fetuses. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Universitätsmedizin

Sprache:

Englisch

Sachgruppe der DNB:

540 Chemie

570 Biowissenschaften, Biologie

610 Medizin, Gesundheit

Veröffentlichung /
Entstehung:

Rostock