| title: |
| Stressors modulating granulosa cell functionality, ovulation and oocyte competence
in bovines |
|
| contributing persons: |
|
| contributing corporate bodies: |
| Universität Rostock[Grad-verleihende Institution] |
 |
38329-6 |
| Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
|
2147083-2 |
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| |
| abstract: |
|
Ovarian follicles are exposed to stressors such as higher levels of non-esterified
free fatty acids (NEFAs) or hypoxia. High follicular levels of NEFA severely affect
granulosa cells (GCs) by targeting key genes of estradiol biosynthesis. Cultured GCs
exposed to hypoxia showed specific regulation of genes that initiate luteinization.
These effects were partly mediated by hypoxia inducible factor1 (HIF1). Thus, ovarian
follicles are susceptible to elevated NEFA levels, but cope up with severe hypoxia
prevailing during late folliculogenesis through specific transcription factors such
as HIF1.
[English] |
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| document type: |
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| institution: |
| Faculty of Mathematics and Natural Sciences |
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| language: |
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| subject class (DDC): |
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| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2020
|
|
| statement of responsibility: |
| vorgelegt von ARPNA Sharma |
|
| notes: |
| Enthält Zeitschriftenartikel |
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| |
| identifiers: |
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| access condition: |
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| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
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|
| RosDok id: |
rosdok_disshab_0000002482 |
| created / modified: |
24.03.2021 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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